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KMID : 1114620130100010017
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Journal of the Korean Society for Breast Screening
2013 Volume.10 No. 1 p.17 ~ p.22
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The Effectiveness of Dynamic Contrast Enhanced MRI and Diffusion Weighted MRI for Evaluating Early Treatment Response of Locally Advanced Breast Cancer to Neoadjuvant Chemotherapy
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Kim Ga-Ram
Kim Eun-Kyung
Kim Min-Jung
Yoon Jung-Hyun
Moon Hee-Jung
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Abstract
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Purpose: To clarify whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusionweighted magnetic resonance imaging (DWI) performed after two cycles of neoadjuvant chemotherapy can be used to predict pathologic complete response (pCR) in patients with breast cancer.
Materials and Methods: Fourteen women who had DCE-MRI and DWI prior to and after two cycles of neoadjuvant chemotherapy due to breast cancer in same consoles had been included. Lesion size and degree of peak enhancement derived from DCE-MRI, and the apparent diffusion coefficient (ADC) value derived from ADC mapping were compared between lesions with and without pathologic complete response (pCR). Interval changes in lesion size, degree of peak enhancement, and ADC value before and after two cycles of chemotherapy were compared.
Results: The initial lesion size with pCR was smaller than those without (P value, 0.855). The initial peak enhancement and ADC value of lesions with pCR was lower than those without, but not significantly different (P values, 0.770 and 0.660). The size and peak enhancement of lesions with pCR were significantly decreased compared with those without (P value, 0.045 and 0.044). The ADC value of lesions with pCR was increased compared with lesions without, but not statistically significant (P value, 0.132).
Conclusion: The lesion size and the degree of peak enhancement were significantly reduced in lesions with pCR after two cycles of neoadjuvant chemotherapy, but a large-scale study is anticipated.
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KEYWORD
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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI),
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